Gene Drug Interaction

How Genes Shape Drug Response: Metabolism, Targets, and the Warfarin Example

Genes significantly impact drug response by altering how the body processes medications (pharmacokinetics) or how drugs interact with their targets (pharmacodynamics). The blood thinner warfarin serves as a prime example, demonstrating how variations in genes like CYP2C9 and VKORC1 collectively influence an individual's optimal dosage.